Cell Lines and Cell Cultures
Eurofins Discoverx PathHunter CHO-K1 GPR27 β-Arrestin Orphan GPCR Cell Line, 2 vials. (93-0334C2A)
The PathHunter GPR27 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand based activation of GPR27 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged GPR27 and EA-tagged β-Arrestin-2. Activation of GPR27 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. This is an orphan receptor without a known ligand. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx Ready-to-Assay FSH Glycoprotein Hormone Receptor Frozen Cells, 2 Vials of Cells. (HTS178LRTA)
The Ready-to-Assay FSH Glycoprotein Hormone Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. follicle stimulating hormone) based activation of FSHR GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses FSHR alongside exogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. ChemiBrite cells also express a clytin variant, allowing for luminescent as well as fluorescent signal detection. Upon activation of FSHR, the resulting calcium activity can be assayed in either detection mode. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
Sciencell Research Laboratories Human Cardiac Myocytes, >1 x 10^6 cells per vial, 1 ml per vial, cryopreserved, delivered frozen, negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, fungi
Human Cardiac Myocytes, >1 x 10^6 cells per vial, 1 ml per vial, cryopreserved, delivered frozen, negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, fungi
Lonza Walkersville DHLF-IPF - Diseased Human Lung Fibroblasts, Idiopathic Pulmonary Fibrosis
IPF (Idiopathic Pulmonary Fibrosis) is a fatal disease that usually affects adults between the ages of 50-70. The disease is characterized by progressive decline in lung function resulting from scarring of lung tissue.Benefits:Gene expression pathways Phenotypic changes to compounds Transfect diseased cells Co-culture with immune cells Airway remodeling studies Cellular interactionContent:1 x Cryopreserved ampule of DHLF-IPF containing ≥500,000 cells
iQ Biosciences Purified Cynomolgus Monkey CD3 Pan T Cells, 10M cells/vial
High-quality, high-viability (> 90%) CD3 Pan T cells purified from cynomolgus (cyno) monkey (or macaque) PBMCs by magnetic selection. Highly enriched (typically > 90%) post-selection purity achieved via magnetic isolation. Used for a wide variety of safety assessment and functional assays. All orders come with an iQ Certificate of Analysis.The following donor requests can be accommodated if inventory is available: - Single or multiple donors for a particular product (SKU). Indicate number of vials from each individual donor - Donor-matched PBMCs
Lonza Walkersville Human Cardiac Microvascular Endothelial Cells, cryopreserved ampule, ≥ 500,000 cells, Passage 3, EGM™-2 MV Growth Medium (CC-3202)
Human Cardiac Microvascular Endothelial Cells (HMVEC-C) are primary cells derived from human heart tissue and are specifically tailored for cardiovascular research. These cryopreserved cells are isolated from both normal and diabetic donors, ensuring a robust platform for various experimental applications. HMVEC-C are subjected to extensive quality testing, guaranteeing their performance across multiple population doublings, while being free from common contaminants.
- Cell type: Primary human cardiac microvascular endothelial cells
- Tissue origin: Heart
- Species: Human
- Donor status: Normal and diabetic donors
- Format: Cryopreserved ampule
- Quantity: ≥ 500,000 cells per ampule
- Passage number at shipment: 3
- Guaranteed population doublings: 10 (primary), 15 (secondary)
- Positive for acetylated low density lipoprotein uptake
- Quality assurance: Certificate of Analysis provided
Cellular Dynamics International iCell Cardiomyocytes, 01434, 4 x 10^6 cells/vial
Heart disease encompasses a wide range of conditions that can be a result of genetics, physiologic, and metabolic disorders as well as adverse drug reactions. The availability of human cell models that could be used to interrogate these various factors would have a profound impact on the effort to find new medicines and cures for heart disease. Derived from induced pluripotent stem cells (iPSCs), iCell Cardiomyocytes from FUJIFILM Cellular Dynamics, Inc. (FCDI), enable a wide range of applications spanning disease research, drug discovery, safety and toxicity testing, and regenerative medicine.
Cellular Dynamics International iCell Neural Base Medium 1, 100 ml, serum-free, liquid
iCell Neural Base Medium 1, 100 ml, serum-free, liquid
Lonza Walkersville HMVEC-dNeo – Human Dermal Microvascular Endothelial Cells, Neonatal, Single Donor
HMVEC-d Neo, Dermal Microvascular Endothelial, Neonatal, Single donor
Invivogen HEK-Blue™ TSLP Cells, Monitors TSLP Induced STAT5 Activation, Colorimetric Bioassay, 1 vial
The InvivoGen HEK-Blue™ TSLP Cells are a robust bioassay tool designed to analyze human TSLP signaling through STAT5 activation, utilizing a colorimetric detection method. Derived from HEK 293 cells, these cells offer high sensitivity and specificity for TSLP research applications, making them ideal for studying immune responses and inflammation. Their stable nature and pre-validation for cytokine testing differentiate them from other options, ensuring reliable and consistent results in research.